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KMID : 0380620230550010050
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Korean Journal of Food Science and Technology
2023 Volume.55 No. 1 p.50 ~ p.56
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In vitro screening of seaweed ethanol extracts for anti-inflammatory and anti-obesity properties
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Qunzhe Wang
Jing Yan
Im Yu-Ri
Bak Jin-Woo
Go Yeon-Gyeong
Lee Kyoung-Youn
Kim Hye-Mee
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Abstract
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Seaweeds contain a high concentration of phenolic and flavonoid compounds with diverse biological activities. This study aimed to determine the total polyphenol and flavonoid content, and thereby the anti-inflammatory and antiobesity properties, of 26 species of algal ethanol extracts through in vitro experiments. According to the data, Eisenia bicyclis, Ecklonia cava, Martensia jejuensis, and Symphyocladia glabra had the highest phenolic and flavonoid content. Most seaweed extracts inhibited lipopolysaccharide (LPS)-induced production of the pro-inflammatory cytokine IL-6 in RAW264.7 cells. Among them, Desmarestia viridis, Ecklonia cava, Sargassum thunbergii, Scytosiphon lomentaria, and Symphyocladia glabra decreased cell viability at 50 mg/L, and significantly inhibited lipid accumulation in 3T3-L1 cells, demonstrating their potential as anti-obesity treatments. These results suggest that Desmarestia viridis and Symphyocladia glabra, which have not been thoroughly studied, have the potential to prevent or treat obesity.
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KEYWORD
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seaweeds, total phenolic contents, anti-inflammatory activity, anti-obesity activity, Symphyocladia glabra
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